THIS WEBSITE IS NOT UPDATED ANYMORE, PLEASE VISIT https://mdmlab.fr/
Selected publications
Tesson F., Hervé A., Touchon M., d’Humières C., Cury J., Bernheim A.
Systematic and quantitative view of the anti-viral arsenal of prokaryotes.
biorRxiv, (2021)
Bernheim A., Millman A., Ofir G., Meitav G., Abraham C., Shomar H., Rosenberg M., Tal N., Melamed S., Amitai G., Sorek R.
Prokaryotic viperins produce diverse antiviral molecules.
Nature, 589, 120-124 (2021)
Millman A*, Bernheim A*, Stokar-Avihail A.*, Fedorenko T., Voichek M., Leavitt A., Sorek R.
Bacterial retrons function in anti- phage defense
Cell, 183 (6), 1551-1561 (2020)
Bernheim A, Sorek R
The bacterial pan-immune system: anti-phage defense as a community resource
Nature Reviews Microbiology 18, 113–119 (2020)
Bernheim A, Bikard D, Touchon M, Rocha EPC:
Atypical organizations and epistatic interactions of CRISPRs and cas clusters in genomes and their mobile gemetic elements
Nucleic Acids Research 48 (2), 748-760 (2020)
Bernheim A, Bikard D, Touchon M, Rocha EPC
A matter of background: DNA repair, pathways as a possible cause for the sparse distribution of CRISPR–Cas, systems in bacteria.
Philosophical Transactions of the Royal Society B 374 (1772), 2018008 (2019)
Bernheim A, Calvo-Villaman A, Basier C, Cui L, Rocha EPC, Touchon M, Bikard D, Inhibition of NHEJ repair by type II-A CRISPR-Cas systems
Nature Communications 8 (1), 1-9 (2017)
All publications
Klompe S, Jaber N, Bel L, Mohabir J, Bernheim A, Sternberg S.
Evolutionary and mechanistic diversity of Type I-F CRISPR-associated transposons
Molecular Cell 82 (3), 616-628e5 (2022)
Tesson F., Hervé A., Touchon M., d’Humières C., Cury J., Bernheim A.
Systematic and quantitative view of the anti-viral arsenal of prokaryotes.
biorRxiv (2021)
Rousset F., Dowding J., Bernheim A, Rocha E.P.C, Bikard D.
Prophage-encoded hotspots of bacterial immune systems.
biorRxiv (2021)
Garb J., LopatinaA., Bernheim A, Zaremba M, Siksnys V, Melamed S, Leavitt A, Millman A, Amitai G, Sorek R
Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion.
biorRxiv (2021)
Decrulle A., Frenoy A., Meiller-Legrand T. , Bernheim A, Lotton C., Gutierrez A., Lindner A. B.
Engineering gene overlaps to sustain genetic constructs in vivo.
Plos Computational Biology 17(10) e1009475 (2021)
Bernheim A., Millman A., Ofir G., Meitav G., Abraham C., Shomar H., Rosenberg M., Tal N., Melamed S., Amitai G., Sorek R.
Prokaryotic viperins produce diverse antiviral molecules.
Nature, 589, 120-124 (2021)
Millman A*, Bernheim A*, Stokar-Avihail A.*, Fedorenko T., Voichek M., Leavitt A., Sorek R.
Bacterial retrons function in anti- phage defense
Cell, 183 (6), 1551-1561 (2020)
Bernheim A, Sorek R
The bacterial pan-immune system: anti-phage defense as a community resource
Nature Reviews Microbiology 18, 113–119 (2020)
Bernheim A, Bikard D, Touchon M, Rocha EPC
Atypical organizations and epistatic interactions of CRISPRs and cas clusters in genomes and their mobile gemetic elements
Nucleic Acids Research 48 (2), 748-760 (2020)
Bernheim A, Bikard D, Touchon M, Rocha EPC
A matter of background: DNA repair, pathways as a possible cause for the sparse distribution of CRISPR–Cas, systems in bacteria.
Philosophical Transactions of the Royal Society B 374 (1772), 2018008 (2019)
Bernheim A, Sorek R
Virus cooperate to defeat bacteria
Nature 559 (7715), 482-484, (News and Views) (2018)
Couvin D., Bernheim A, Toffano-Nioche C., Touchon M., Michalik J., Néron B, Rocha EPC, Vergnaud G., Gautheret D., Pourcel C.
CRISPRCasFinder, an update of CRISRFinder, includes a portable version, enhanced performance and integrates search for Cas proteins.
Nucleic Acids Research 46 (W1), W246-W251 (2018)
Rendueles, O, de Sousa, J, Bernheim A, Touchon M, Rocha EPC
Genetic exchanges are more frequent in bacteria encoding capsules. R
PLoS Genetics (14(12) 1-25 (2018)
Bernheim A, Calvo-Villaman A, Basier C, Cui L, Rocha EPC, Touchon M, Bikard D
Inhibition of NHEJ repair by type II-A CRISPR-Cas systems
Nature Communications 8 (1), 1-9 (2017)
Depardieu,F, Didier J.P, Bernheim A, Sherlock A, Molina H. Duclos B, Bikard D,.
A Eukaryotic-like Serine/Threonine Kinase Protects Staphylococci against Phages
Cell Host and Microbes 20 (4), 471-481 (2016)
Touchon M, Bernheim A, Rocha EPC
Genetic and life-history traits associated with the distribution of prophages in bacteria.
ISME Journal 10 (11), 2744-2754 (2016)
Bernheim A.*, Libis V.*, Lindner A., Wintermute E.,
Phage-mediated Delivery of Targeted sRNA Constructs to Knock Down Gene Expression in E. coli
Journal of Visualized Experiments 109 e53618 (2016)
Libis, V*, Bernheim, A*, Basier C, Deyell M, Aghoghogbe I, Atanaskovic, I, Amel C, Benony M, Koustoubelis N, Lochner A, Marinkovic Z, Zahra S, Zegman Y, Lindner AB, Wintermute EH
Silencing of antibiotic resistance in E. coli with engineered phage bearing small regulatory RNAs.
ACS Synthetic Biology 3 (12), 1003-1006 (2014)
Atanaskovic I, Bencherif C, Deyell M, Jaramillo-Riveri M, Benony M, Bernheim A, Libis V, Koustoubelis A, Zegman Y, Lochner A, BasierC, afhoghobe I, Marinkovic Z, Zahra S, Toulouze M, Lindner AB, Wintermute EH
Characterization of Mycobacterial Growth Inhibition by Lytic Enzymes Expressed in Vectorized E. coli In Situ
ACS Synthetic Biology 3 (12), 932-934 (2014)
Snell C, Bernheim A, Bergé JB, Kuntz M, Pascal G, Paris A, Ricroch AE
Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: A literature review.
Food and Chemical Toxicology 50 (3-4) 1134-48 (2012)
Aude Bernheim 